Weight-loss center Profile by Sanford opened a League City location at 2875 E. League City Parkway, Ste. 350, Oct. 30. The business provides nutrition, activity and lifestyle coaching to help people lose weight and keep it off. Sanford Health researchers and physicians created Profile to take the guesswork out of health living, according to an employee. The business also has new locations in Friendswood and Katy. 281-672-9040. www.profileplan.com/league-city