The county had been unaware of the cases until the Texas Department of State Health Services brought them to its attention, according to the information released.
Three of the new cases were in New Braunfels and the fourth patient's location had not been confirmed.
All new patients are self-quarantined in their homes, and two of the new cases were from the same household.
To date, Guadalupe's Office of Emergency Management has reported 57 cases of the virus, with 33 patients recovered and one hospitalized. There are 24 active cases confirmed by the county.
Of Guadalupe County's cases, 10 are from its side of New Braunfels. Comal County has confirmed 14 distinct cases within its coverage of New Braunfels, making for 24 total cases in the city.
Comal County marked Saturday as the third day in a row with no new cases to report. 581 tests have been reported to Comal County's Office of Public Health (OPH).
Health officials from the OPH have said that the peak of the virus outbreak In Comal County is two or three weeks away.
Guadalupe County has not reported testing numbers.