Both patients live in households with previously reported cases. One is aged in their 30s and lives in Garden Ridge, while the other is a Spring Branch-area resident in their 50s.
They are both under self-quarantine.
As of April 21, Comal County's Office of Public Health (OPH) has confirmed 45 local cases of the virus since the pandemic's first positive test in Comal on March 18.
There have been 32 patient recoveries and six deaths among those cases. Seven cases are still active and two are hospitalized.
The OPH has received reports of 594 tests conducted as of Tuesday morning. The pace at which tests have been reported has slowed over the last week.
Last week, OPH Director Cheryl Fraser told the Comal County Commissioners Court that the local peak for the coronavirus is still two or three weeks away. Fraser also said she expected a bump in cases due to residents going out during Easter Weekend.
On April 20, Guadalupe County's Office of Emergency Management announced two new cases, bringing its total to 60. Those residents are also self-quarantined.
The Office of Emergency Management has reported 40 recoveries, and one Guadalupe resident is hospitalized.
New Braunfels has 25 cases across both counties—the most of any city in either county. Cibolo, which is on the edge of Bexar County, has 20 confirmed cases. Bexar has more than 1,000 positive tests.