The shutdown will run from 9 p.m. Friday, June 5 until 5 a.m. Monday, June 8.
Crews will continue working on placing bridge beams for a new I-610 West Loop southbound connector to northbound I-69 Southwest Freeway, according to the Texas Department of Transportation.
TxDOT advises motorists to plan for delays and look for alternate routes. Police will assist with traffic control.
Find detour information and additional road closure updates at www.houstontranstar.org.