Two of Guadalupe's confirmed cases are in New Braunfels, just across the county line.
At least two of the most recent patients in Comal are considered by the county's Office of Public Health to have contracted the disease from interactions within the community.
One of the patients is in their 40s and is hospitalized. There are now four Comal residents hospitalized in either Travis or Bexar County.
The other new patients are in their 30s and 70s.
One patient is from New Braunfels, another is from north of Canyon Lake and the last is from the Smithson Valley area near Bulverde, according to information released by the county.
Comal and Guadalupe issued stay-at-home orders in parallel on Friday and both are active through April 30.
Guadalupe County also amended its disaster declaration so that foreclosure proceedings are stalled for at least the next 30 days, with the potential for the ruling to be extended. Comal has not followed Guadalupe's lead as of this story's publication.
Six of Comal's patients have recovered as of Friday, April 3, and are no longer under self-quarantine.
In the neighboring Guadalupe County, there are 23 confirmed cases as of Thursday, April 2.
A drive-thru testing center is now operating in New Braunfels and there are several private clinics that are performing coronavirus testing.
Hotlines have been set up for people with questions or concerns about the virus. Comal County's can be reached at 830-221-1120. New Braunfels' hotline can be reached at 830-221-4222. Both are available from 8 a.m.-5 p.m. on weekdays.